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Megaloblastic Anemia

Megaloblastic Anemia

Megaloblastic Anemia¬†are a heterogeneous group of disorders that share common morphologic characteristics. Erythrocytes are larger & have higher nuclear-to-cytoplasmic ratios compared to normal cells Neutrophils can be hypersegmented Megakaryocytes are abnormal On the cellular level in megaloblastic cells, the maturation of nucleus is delayed, while cytoplasmic development is normal & is characterized by sizable red blood cells. This malformation causes the bone marrow to produce fewer cells, & sometimes the cells die earlier than the normal 120-day life expectancy. In lieu of being round or disc-shaped, the red blood cells can be oval. Megaloblastic anemia is an anemia that results […]

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Thalassemia

Thalassemia:- Thalassemia is a type of blood disorder that is inherited. In this disorder, the body makes an abnormal type of hemoglobin (the oxygen carrying protein in the body). This condition involves an excessive destruction of the red blood cells in the body which leads to anemia. What causes Thalassemia? Hemoglobin is made up of two protein chains: alpha chains and beta chains. Thalssemia occurs when there is a defect in the production of any one of these globin chains. There are two types of thalassemias: 1. Alpha Thalssemia: This occurs when the alpha globin chain in the hemoglobin molecule […]

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Sickle cell anemia

Sickle cell anemia is the most common form of sickle cell disease. Sickle cell disease is a genetically inherited disorder in which our body makes abnormally shaped sickled red blood cells. The sickled red blood cells take their name from the fact that they are shaped like a sickle (or a crescent). Difference between normal red blood cells and sickle cells Normal red blood cells are biconcave discs. They are elastic so can squeeze and stretch through the blood vessels. They contain an oxygen carrying pigment called hemoglobin in them. This pigment is the protein responsible for carrying oxygen bound […]

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Multiple Myeloma Symptoms

Multiple Myeloma Symptoms are caused by plasma cell abnormalities. Multiple myeloma is a type of cancer which involves the plasma cells in the blood. Plasma cells are a type of white blood cells in the body which are responsible for making antibodies. These antibodies help your body fight infection. In multiple myeloma these abnormal cells accumulate in the bone marrow and then interfere with the production of normal red blood cells. What happens in multiple myeloma? In multiple myeloma, one type of plasma cells called myeloma cells increase in number. They become cancerous and multiply so that they crowd the […]

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